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To get the maximum benefit from your medication, it is advisable not to drink excessive amounts of alcohol before taking this medication. A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products (except nitrates). The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. When the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in increased corpus cavernosum levels of cGMP.

For most people, it’s recommended that you take Viagra as needed, about 1 hour before you plan to have sex. But Viagra can actually be taken anywhere from 30 minutes to 4 hours before sexual activity. You shouldn’t take Viagra if you’re taking the pulmonary arterial hypertension (PAH) drugs listed below. Taking Viagra with these medications can cause your blood pressure to drop too low. Low blood pressure from Viagra usually isn’t a problem for most people.

Other treatments for ED include topical applications, injections into the penis, surgical devices, penis pumps, and counselling. Other oral ED drugs work in a similar way, with similar side effects. Viagra was the first drug in this class to become widely prescribed.

How effective and long Viagra lasts in your system also depends on your pre-existing health conditions. To err on the safe side, we recommend that you consult a medical professional before consuming Viagra. Viagra generally starts working within 30 to 60 minutes after consumption. To determine what initial dosage is best for you, we recommend seeking professional advice from trained doctors, which we offer here at Noah.

There do not appear to be any long-term side effects from taking it. However, if you have certain medical conditions, you should consult with your doctor to check that it is safe for you to take. You should always let your doctor or pharmacist know of any medication you are taking, or planning to take, including recreational drugs. It may still be possible to take sildenafil, but adjustments to the dosage may be suggested. You can buy sildenafil tablets online from our UK-registered pharmacy without the need for a prescription from your GP.

Below are lists of medications that can interact with Viagra. These lists don’t contain all the drugs that may interact with Viagra. If you drink alcohol, talk with your doctor about how much is safe for you to drink while you’re taking Viagra. The manufacturer of Viagra doesn’t give any specific warnings about drinking alcohol while using this drug. But in general, it’s best to avoid drinking lots of alcohol with the medication. Keep in mind that Viagra isn’t approved in the United States to treat PE.

So aside from keeping your Sildenafil close by or in your bedside draw, you don’t need to plan very far in advance before sex – which gives you extra flexibility and peace of mind. Even if you’re a man with a very active sex life, you should be covered. While it’s possible to take Sildenafil every day, there is a restriction on the daily dosage. In any case, studies have shown that a higher dose than 100mg in one day doesn’t have any added benefit – and could increase the chances of side effects.

For example, you should not take Viagra if you take nitrate medications to treat chest pain. You should also avoid taking Viagra if you take a drug called riociguat (Adempas). Taking Viagra with these medications can cause a dangerous drop in your blood pressure that leads to heart attack or stroke. If you’re sexually aroused, Viagra should work to help you get or keep an erection within 30 minutes to 2 hours.

Avanafil is the active ingredient in Spedra tablets which tackles ED. It is a PDE-5 inhibitor — a drug that increases the blood flow to your penis once you have become aroused. This blood flow will only occur during sexual stimulation